In Vitro Bioactivity Evaluation of IL-4 and SDF-1 Mimicking Peptides Engineered to Enhance Skeletal Muscle Reconstruction [0.03%]
模拟IL-4和SDF-1的肽对骨骼肌重建作用的体外生物活性评估研究
Zuzanna Michalska,Anna Ostaszewska,Martyna Fularczyk et al.
Zuzanna Michalska et al.
Skeletal muscle regeneration depends on satellite cells, which, in response to injury, activate, proliferate, and reconstruct damaged tissue. However, under certain conditions, such as large injuries or myopathies, this process may not be p...
Bioactivity Evaluation and Phytochemical Characterization of Euonymus alatus (Thunb.) Siebold Leaf Extract [0.03%]
卫矛叶提取物的体外生物活性评价及植物化学成分分析
Won-Joo Yoon,Hye-Ji Min,Hyun-Dong Cho et al.
Won-Joo Yoon et al.
Background: Euonymus alatus (E. alatus) has traditionally been used for medicinal purposes, and its leaves are considered edible. While E. alatus is known for its diverse biological activities, the antioxidant, antidiabet...
Multi-functional tyrosinase inhibitors derived from kojic acid and hydroquinone-like diphenols for treatment of hyperpigmentation: Synthesis and in vitro biological evaluation [0.03%]
从曲酸和对苯二酚类似物合成的用于治疗色素沉着的多功能酪氨酸酶抑制剂：体外生物活性评价
Morteza Ashooriha,Mehdi Khoshneviszadeh,Maryam Kabiri et al.
Morteza Ashooriha et al.
A series of multi-functional tyrosinase inhibitors derived from kojic acid (KA) and hydroquinone-like diphenols were designed and synthesized using click chemistry. The in vitro enzymatic assay revealed that all compounds containing a free ...
Isolation and In Vitro Biological Evaluation of Triterpenes from Salacia grandifolia Leaves [0.03%]
大叶降糖藤叶三萜类成分的分离及其体外生物活性评价
Leila Renan Oliveira,Mateus Sá Magalhães Serafim,Diego Lanza Dias et al.
Leila Renan Oliveira et al.
Salacia grandifolia is naturally found in the Atlantic Forest regions of Brazil. Despite the pharmacological potential of plants from the Salacia genus, phytochemical studies on this species have not been reported in literature. A new trite...
A synthesis of (±)-thia-calanolide A, its resolution and in vitro biological evaluation [0.03%]
(±)-硫杂环氯烷啶A的合成、拆分及体外生物活性评价
Anil U Chopade,Manojkumar U Chopade,Bhanu M Chanda et al.
Anil U Chopade et al.
A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel-Crafts tigloylation of 5,7-dihydroxy-4-n-propyl ...
Copper-mediated cyclization of thiosemicarbazones leading to 1,3,4-thiadiazoles: Structural elucidation, DFT calculations, in vitro biological evaluation and in silico evaluation studies [0.03%]
铜介导的硫代半卡巴腙向1,3,4-噻二唑的环化：结构确定，DFT计算，体外生物活性评价和计算机评估研究
Vipin Manakkadan,Jebiti Haribabu,Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam et al.
Vipin Manakkadan et al.
Cancer's global impact necessitates innovative and less toxic treatments. Thiosemicarbazones (TSCs), adaptable metal chelators, offer such potential. In this study, we have synthesized N (4)-substituted heterocyclic TSCs from syringaldehyde...
Synthesis, in silico studies, and in vitro biological evaluation of newly-designed 5-amino-1 H-tetrazole-linked 5-fluorouracil analog as a potential antigastric-cancer agent [0.03%]
新设计的5-氨基-1 H-四唑连接的5-氟尿嘧啶类似物的合成，计算机模拟研究和体外生物活性评价作为潜在的抗胃癌药物
Javad Nowdehi,Elaheh Mosaddegh,Samad Khaksar et al.
Javad Nowdehi et al.
5-Fluorouracil (5FU) is a chemotherapy drug used to treat various cancers, such as colorectal, prostate, skin, pancreas, and stomach, as an ointment or solution. However, its consumption has several side effects. Therefore, a new derivative...
3,4-Diarylisoxazoles-Analogues of Combretastatin A-4: Design, Synthesis, and Biological Evaluation In Vitro and In Vivo [0.03%]
3,4-二芳基异噁唑-作为combretastatin A-4的类似物：设计，合成及在体外和体内生物学评价
Georgy L Karetnikov,Lilya A Vasilyeva,Gulalek Babayeva et al.
Georgy L Karetnikov et al.
Focusing on the molecular docking results, a series of 3,4-diarylisoxazoles, analogues of Combretastatin A4, bearing various substituents at the fifth position of the isoxazole ring and pharmacophore groups bioisosteric to methoxy substitue...
Characterization and in vitro bioactivity evaluation of polyvinyl alcohol incorporated electro spun chitosan/ fluor apatite nanofibrous scaffold for bone tissue engineering [0.03%]
聚乙烯醇掺杂电纺壳聚糖/氟磷灰石纳米纤维支架的特性及体外生物活性评价在骨组织工程中的应用
Fatemeh Mirjalili,Mahboobeh Mahmoodi,Shiva Khazali
Fatemeh Mirjalili
In this study, polyvinyl alcohol/chitosan/fluor apatite scaffolds with different concentrations of polyvinyl alcohol of 0.075 g ml-1 and 0.1 g ml-1, respectively named A and B fabricated by electrospinning method to use in tissue engineerin...
The Synthesis, In Vitro Bio-Evaluation, and In Silico Molecular Docking Studies of Pyrazoline-Thiazole Hybrid Analogues as Promising Anti-α-Glucosidase and Anti-Urease Agents [0.03%]
吡唑啉并噻唑衍生物的合成，体外生物活性评价和基于计算机分子对接研究作为潜在的抗-α-葡萄糖苷酶和抗尿素酶试剂
Yousaf Khan,Shoaib Khan,Rafaqat Hussain et al.
Yousaf Khan et al.
In the present work, a concise library of benzothiazole-derived pyrazoline-based thiazole (1-17) was designed and synthesized by employing a multistep reaction strategy. The newly synthesized compounds were screened for their α-glucosidase...
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