Corrigendum to "Supratherapeutic concentrations of cilostazol inhibits β-amyloid oligomerization in vitro" [Neurosci. Lett. 677 (2018) 19-25/ NSL_33555] [0.03%]
有关“西洛他唑超治疗浓度通过抑制β淀粉样蛋白低聚化来改善学习和记忆”一文的勘误(神经科学研究快报)[Neurosci. Lett. 677 (2018) 19-25/ NSL_33555]
Hidenobu Shozawa,Tatsunori Oguchi,Mayumi Tsuji et al.
Hidenobu Shozawa et al.
Published Erratum
Neuroscience letters. 2025 Jun 5:138285. DOI:10.1016/j.neulet.2025.138285 2025
Development of Flow-NMR Spectroscopy for Real-Time Monitoring and Kinetics Studies of Biomolecules: Case Study of Liraglutide Oligomerization [0.03%]
用于生物分子实时监测和动力学研究的流体NMR光谱技术的发展及利拉鲁肽低聚化物的实例研究
Xingjian Xu,Guilherme Dal Poggetto,Yingkai Liang et al.
Xingjian Xu et al.
We report the development of a comprehensive flow-NMR methodology for mechanistic studies of biomolecules. This approach allows for systematic kinetic investigation via precise sample condition modulations. Traditionally utilized for reacti...
PRDX5 and PRDX6 translocation and oligomerization in bull sperm: a response to cryopreservation-induced oxidative stress [0.03%]
精子过氧化物酶5和6在冷冻保存诱导的氧化应激下的易位及寡聚化作用机制研究
Mostek-Majewska Agnieszka,Bossowska-Nowicka Magdalena,Słowińska Mariola et al.
Mostek-Majewska Agnieszka et al.
Cryopreservation of bull sperm, crucial for breeding and assisted reproduction, often reduces sperm quality due to oxidative stress. This study examines how oxidative stress during cryopreservation affects peroxiredoxin 5 (PRDX5) and peroxi...
Eleftherios Mainas,Gregory M Curtin,Shaena D Riddles et al.
Eleftherios Mainas et al.
Sandercyanin is a mildly fluorescent biliprotein with a large Stokes shift, a tetrameric quaternary structure, and a biliverdin (BV) chromophore that does not covalently bond to the protein. To adapt this promising protein for use in bioima...
Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis [0.03%]
识别出靶向GSDMD寡聚化界面I的两种老药以阻断细胞焦亡
Yingchao Hu,Honghui Li,Xiangyu Zhang et al.
Yingchao Hu et al.
As an executor of pyroptosis, gasdermin D (GSDMD) plays a critical role in inflammatory diseases and cancer. Thus, GSDMD is currently being widely explored as a drug target. Existing inhibitors targeting GSDMD, such as necrosulfonamide, dis...
Oligomerization and positive feedback on membrane recruitment encode dynamically stable PAR-3 asymmetries in the C. elegans zygote [0.03%]
寡聚化和膜募集的正反馈编码了秀丽隐杆线虫卵细胞中的动态稳定的PAR-3不对称性
Charlie Lang,Ondrej Maxian,Alexander Anneken et al.
Charlie Lang et al.
Studies of PAR polarity have emphasized a paradigm in which mutually antagonistic PAR proteins form complementary polar domains in response to transient cues. A growing body of work suggests that the oligomeric scaffold PAR-3 can form unipo...
The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease [0.03%]
SORL1 p.Y1816C突变通过干扰早期内体低聚化引起显性遗传阿尔茨海默病
Anne Mette G Jensen,Jan Raska,Petr Fojtik et al.
Anne Mette G Jensen et al.
Truncating genetic variants of SORL1, encoding the endosome recycling receptor SORLA, have been accepted as causal of Alzheimer's disease (AD). However, most genetic variants observed in SORL1 are missense variants, for which it is complica...
Oligomerization and a distinct tRNA-binding loop are important regulators of human arginyl-transferase function [0.03%]
寡聚化和特异的tRNA结合环是人蛋白质精氨酰-tRNA合成酶功能的重要调控因素
Xin Lan,Wei Huang,Su Bin Kim et al.
Xin Lan et al.
The arginyl-transferase ATE1 is a tRNA-dependent enzyme that covalently attaches an arginine molecule to a protein substrate. Conserved from yeast to humans, ATE1 deficiency in mice correlates with defects in cardiovascular development and ...
Measurement of solubility product reveals the interplay of oligomerization and self-association for defining condensate formation [0.03%]
溶度积测定揭示低聚物化和自缔合在凝聚体形成中的相互作用
Aniruddha Chattaraj,Zeynep Baltaci,Steve Chung et al.
Aniruddha Chattaraj et al.
Cellular condensates often consist of 10s to 100s of distinct interacting molecular species. Because of the complexity of these interactions, predicting the point at which they will undergo phase separation is daunting. Using experiments an...
Oligomerization regulates the interaction of Gemin5 with members of the SMN complex and the translation machinery [0.03%]
寡聚化调节Gemin5与SMN复合体成员和翻译机制的相互作用
Rosario Francisco-Velilla,Salvador Abellan,Azman Embarc-Buh et al.
Rosario Francisco-Velilla et al.
RNA-binding proteins are multifunctional molecules impacting on multiple steps of gene regulation. Gemin5 was initially identified as a member of the survival of motor neurons (SMN) complex. The protein is organized in structural and functi...
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