PFKM-Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation [0.03%]
乳酸过生成心房颤动的新机制：诱导心脏纤维母细胞组蛋白乳酸化
Ning Fang,Ning Zhang,Xiaohui Jiang et al.
Ning Fang et al.
Increasing evidence has clarified that atrial fibrillation (AF) is associated with enhanced glycolysis, leading to lactate accumulation. However, whether glycolysis promotes AF remains unknown, as does whether histone lactylation plays a ro...
Gastrodin mitigates aortic valve calcification by inhibiting glycolysis and histone lactylation through interfering with valve interstitial cells [0.03%]
姜半夏缓解主动脉瓣钙化通过干扰瓣间质细胞抑制糖酵解和组蛋白乳酸化
Yu Zhang,Shunshun Wang,Jiaqin Wu et al.
Yu Zhang et al.
Calcific aortic valve disease (CAVD) is the most common disease of the heart valves and is characterised by thickening, fibrosis and calcification of the aortic valve leaflets. Gastrodin, the active component of the traditional Chinese medi...
Corrigendum to "AARS1-mediated Osterix lactylation promotes its transcriptional activity during osteoblast differentiation" [Acta Histochem. 127 (2025) 152273] [0.03%]
“AARS1介导的Osterix乳酸化促进成骨细胞分化过程中的转录活性”一文中“材料与方法”部分存在错误英文标题的中文翻译： Correction to “AARS1-mediated Osterix lactylation promotes its transcriptional activity during osteoblast differentiation”
Feige Nian,Linfeng Guo,Zhangli Fei et al.
Feige Nian et al.
Published Erratum
Acta histochemica. 2025 Jun 23:152275. DOI:10.1016/j.acthis.2025.152275 2025
Yu Gu,Keyang Chen,Chunyan Lei et al.
Yu Gu et al.
Research into lactylation modifications across various target organs in both health and disease has gained significant attention. Many essential life processes and the onset of diseases are not only related to protein abundance but are also...
Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neurons [0.03%]
氨肽酶通过增强糖酵解刺激感觉神经元组蛋白乳酸化参与神经病理性疼痛产生
Yu-Tao Deng,Longfei Ma,Yixiao Mei et al.
Yu-Tao Deng et al.
The genesis of neuropathic pain after peripheral nerve injury is associated with changes in gene expression and cell metabolism in sensory neurons and the release of inflammatory cytokines. Here, we connected glycolytic metabolism induced b...
Prognostic value and immune infiltration analysis of a novel lactylation-related gene signature in endometrial cancer [0.03%]
基于乳酸化的新型基因标志物在子宫内膜癌预后价值及免疫浸润分析中的作用研究
Liqin Gu,Chunnian Zhang,Minjuan Xu et al.
Liqin Gu et al.
Background: Lactylation has been implicated in tumor growth, proliferation, and metastasis; however, its precise relationship with cancer remains poorly understood. This study aims to elucidate the role of lactylation-rel...
AARS1-mediated Osterix lactylation promotes its transcriptional activity during osteoblast differentiation [0.03%]
AARS1介导的Osterix乳酸化在成骨细胞分化过程中促进其转录活性
Feige Nian,Linfeng Guo,Zhangli Fei et al.
Feige Nian et al.
AARS1 is a newly reported lactyl-transferase that plays vital roles in tumorigenesis and innate immune response. However, the function of AARS1-mediated lactylation in osteoblast differentiation is still unclear. Here, we found that silenci...
Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation [0.03%]
PPARα激活可使胶质母细胞瘤细胞对替莫唑胺敏感并逆转获得性抗药性并通过抑制H3K18乳酸化发挥作用
Zhen-Chuan Wang,Chen Li,Zhao Zhang et al.
Zhen-Chuan Wang et al.
Temozolomide (TMZ) is an alkylating agent recommended as the first-line pharmaceutical for glioblastoma (GBM), but its efficacy is limited by the development of acquired resistance in GBM cells. TMZ resistance is regulated by multiple facto...
Hypoxia Promotes the In Vitro Proliferation of Buffalo Spermatogonial Cells by Increasing Lactate and H3K18la Lactylation Levels [0.03%]
缺氧通过增加乳酸和H3K18精氨酸乳酸化水平促进水牛 spermatogonial 体外增殖
Mengqi Li,Yanyu Ma,Shenzhi Wang et al.
Mengqi Li et al.
Hypoxia benefits the proliferation and maintenance of animal spermatogonial cells; however, the underlying mechanism remains incompletely understood. This study aims to investigate the role and mechanism of the hypoxia-glycolysis-histone la...
Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age-related macular degeneration pathology [0.03%]
组蛋白乳酸化和ALKBH3介导的糖酵解之间的反馈调节调控年龄相关性黄斑变性的病理发展
Ying Wang,Yi-Chen Zhang,Zi-Qin Ding et al.
Ying Wang et al.
Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly. It is characterized by degeneration of the retinal pigment epithelium (RPE), which can develop into choroidal neovascularization (CNV) to cause severe...
耗时 0.26656 秒，为您在
48285708
条记录里面共找到 399 篇文章 [XML]