Adaptation of Clinical Research Staff to Decentralized Clinical Trials and Impacts on the Patient-Centered Experience: Qualitative Interview Study [0.03%]
临床研究人员对去中心化临床试验的适应及其对以患者为中心体验的影响：定性访谈研究
Eoin Gamble,Ciara Heavin,Conor Linehan
Eoin Gamble
Background: Industry stakeholders, academic experts, and regulatory bodies emphasize the importance of prioritizing a patient-centered experience in clinical trials to enhance retention, adherence, and trial participation...
Feasibility of a Mind-Body Program for Chronic Pain: A Randomized Clinical Trial [0.03%]
身心计划治疗慢性疼痛的可行性临床研究
Jonathan Greenberg,Julia E Hooker,Katherine A McDermott et al.
Jonathan Greenberg et al.
Importance: Increasing physical function for individuals in chronic pain is challenging. Despite the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials guidelines, no pain trial has comprehensively...
Randomized Controlled Trial
JAMA network open. 2025 Jun 2;8(6):e2515685. DOI:10.1001/jamanetworkopen.2025.15685 2025
The Ave-Rec trial: Phase II trial of PDL1/PD-1 blockade with Avelumab post Chemoradiotherapy for locally advanced resectable T3B-4/N1-2 Rectal cancer [0.03%]
Ave-Rec试验：术前放化疗后应用avelumab阻断PD-L1/PD-1二期临床研究治疗T3B-4期/N1-2期局部晚期直肠癌患者
Michael Michael,Rachel Wong,Sanjeev Gill et al.
Michael Michael et al.
Purpose: Long course chemoradiotherapy (LCCRT) for locally advanced rectal cancer (LARC) results in 10-30% pathological complete response rate (pCR). Radiotherapy is both immuno-stimulatory and -suppressive. PDL1-inhibiti...
Clinical Investigation of Tyrosinase Inhibitors: Past, Present, and Future [0.03%]
酪氨酸酶抑制剂的临床研究：过去、现在和未来展望
Yuanyuan Wang,Ruijia Jiang,Baichen Xiong et al.
Yuanyuan Wang et al.
Tyrosinase (EC 1.14.18.1) is a pivotal enzyme that catalyzes the conversion of L-tyrosine to dopaquinone through a dual oxidation process, initiating melanin biosynthesis. Melanin plays a critical role in various biological processes, and i...
Granulocyte Colony Stimulating Factor (G-CSF) and Olfactory Function-A Clinical Pilot Study [0.03%]
粒细胞集落刺激因子(G-CSF)与嗅觉功能的临床初步研究
C A Hintschich,K Resler,C Brückner et al.
C A Hintschich et al.
Background: Although the olfactory epithelium, including its neuronal cell line, has inherent regenerative potential, therapeutic options remain limited. Promising effects of granulocyte colony stimulating factor (G-CSF) ...
Anti-OX40 antibody BAT6026 in patients with advanced solid tumors: A multi-center phase I study [0.03%]
抗OX40抗体BAT6026治疗晚期实体瘤的多中心Ⅰ期临床研究
Huaqiang Zhou,Yuxiang Ma,Yongsheng Li et al.
Huaqiang Zhou et al.
BAT6026 is a fully human IgG1 OX40 monoclonal antibody. This was a multicenter, open-label, dose escalation, and dose expansion phase I study of BAT6026 conducted in patients with advanced solid tumors who failed standard treatment. Patient...
Charles L Saltzman,Robert B Anderson,Brad D Blankenhorn et al.
Charles L Saltzman et al.
Prenatal Diagnosis of Arachnoid Cysts Without Extra-Central Nervous System Anomalies in the Korean Population: A Multi-Center Retrospective Study on Postnatal Diagnosis and Clinical Outcomes [0.03%]
无额外中枢神经系统畸形的蛛网膜囊肿的产前诊断：一项关于产后诊断和临床结局的多中心回顾性研究
Subeen Hong,Young Mi Jung,Hyun-Joo Seol et al.
Subeen Hong et al.
Background: The aim of our study was to investigate the clinical characteristics, discrepancies in postnatal diagnosis, and outcomes of prenatally diagnosed arachnoid cysts without extra-CNS anomalies. ...
Multicenter Study
Molecular genetics & genomic medicine. 2025 Jun;13(6):e70116. DOI:10.1002/mgg3.70116 2025
Noninsulated Microneedle Radiofrequency for Skin Rejuvenation: A Histological, Transcriptomic and Clinical Study [0.03%]
一种用于皮肤年轻化的非绝缘微针射频的组织学、转录组和临床研究
Jiayi Feng,Lvping Huang,Jun Qi et al.
Jiayi Feng et al.
Background: The efficacy and safety of microneedle radiofrequency (MRF) for antiaging skin treatment has already been demonstrated. This study aims to, for the first time, comprehensively interpret the short and long-term...
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