Advancing CNS tumor diagnostics with expanded DNA methylation-based classification [0.03%]
基于扩增的DNA甲基化分类的中枢神经系统肿瘤诊断研究进展
Martin Sill,Daniel Schrimpf,Areeba Patel et al.
Martin Sill et al.
DNA methylation-based classification is now central to contemporary neuro-oncology, as highlighted by the World Health Organization (WHO) classification of central nervous system (CNS) tumors. We present the Heidelberg CNS Tumor Methylation...
Factors influencing caregiver burden during perioperative care for children with pediatric central nervous system tumors: an analysis of multidimensional burden and associated determinants [0.03%]
影响儿童中枢神经系统肿瘤围手术期护理者的负担因素：多维负担及关联决定因素的分析
Yanjun Yang,Jiahui Fu,Yuwen Fu et al.
Yanjun Yang et al.
Objectives: To investigate the care burden of caregivers of children with central nervous system (CNS) tumors during the perioperative period and analyze the influencing factors of this burden. ...
Glioma-related epilepsy in patients with newly diagnosed and recurrent glioblastoma, IDH-wildtype: a study under the 2021 WHO CNS tumor classification [0.03%]
2021年WHO中枢神经系统肿瘤分类下的新诊断和复发IDH野生型胶质母细胞瘤患者的胶质瘤相关性癫痫研究
Xing Fan,Jianli Dai,Jiajia Liu et al.
Xing Fan et al.
DNA Methylation-Based Classification for Central Nervous System Tumours: A Health Technology Assessment [0.03%]
中枢神经系统的肿瘤甲基化分类：一项卫生技术评估报告
Ontario Health (Quality)
Ontario Health (Quality)
Background: Central nervous system (CNS) tumours occur when abnormal cells form in the tissues of the brain and/or spinal cord. Conventional testing for CNS tumour classification involves histopathological evaluation and ...
Translational role of molecular biomarkers in developing targeted therapies for central nervous system tumors [0.03%]
分子生物标志物在中枢神经系统肿瘤靶向治疗中的转化作用
Jaishriram Rathored,Tanushree Budhbaware,Sushma Chauhan et al.
Jaishriram Rathored et al.
Background: The identification of biomarkers has led to the discovery of new pathways for precision diagnostics and tailored therapies in neoplasms of the central nervous system, thereby enhancing prognoses due to their d...
A Phase 1 Trial of Fimepinostat in Children and Adolescents With Relapsed and Refractory Solid and CNS Tumors [0.03%]
菲美匹诺特治疗复发和难治性实体瘤和中枢神经系统肿瘤的I期临床试验
David S Shulman,Kieuhoa T Vo,Frank M Balis et al.
David S Shulman et al.
Background: Fimepinostat, an oral dual inhibitor of histone deacetylase (HDAC) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), has shown activity in preclinical models of Myc-driven pediatric malignancies. This...
Clinical Trial
Cancer medicine. 2025 Dec;14(23):e71417. DOI:10.1002/cam4.71417 2025
Comprehensive Updates on Central Nervous System Neoplasms in Pediatric Neuroradiology [0.03%]
儿科神经放射学中枢神经系统肿瘤的全面更新
Jane C McEniery,Christopher Risto G Filippi
Jane C McEniery
Murat Alp Oztek,Jason N Wright
Murat Alp Oztek
Central nervous system (CNS) embryonal tumors are a subset of aggressive pediatric brain tumors, more frequently seen in infants and young children. They share an aggressive imaging appearance with frequent disseminated disease and guarded ...
Aashim Bhatia,Em Triolo,L Tyler Williams et al.
Aashim Bhatia et al.
The 23Na-MRI technique from acquisition to postprocessing provides many opportunities and potential advantages or augmentations over 1H-MR imaging alone, and over prior preliminary 23Na-MRI approaches. The current implementation provides im...
Artificial Intelligence and Radiogenomics for Pediatric CNS Neoplasms [0.03%]
人工智能和影像基因组学在儿科中枢神经系统肿瘤中的应用
Mario Tortora,Aline Ayres,Suely Fazio Ferraciolli
Mario Tortora
The 5th edition of the WHO CNS tumor classification (2021) emphasizes molecular alterations, especially in pediatric tumors, integrating histology with molecular profiling for precise diagnosis. Advances like DNA methylation profiling and N...
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