PruEV-AI: a Simple Approach Combines Urinary Extracellular Vesicle Isolation with AI-Assisted Analysis for Prostate Cancer Diagnosis [0.03%]
结合尿液外泌体与人工智能分析的前列腺癌诊断新方法PruEV-AI
Minju Lee,Bonhan Koo,Myoung Gyu Kim et al.
Minju Lee et al.
Urinary extracellular vesicles (uEVs) are a promising source of prostate-derived biomarkers for non-invasive prostate cancer (PCa) diagnosis. However, conventional uEV isolation methods and single-marker assays often lack efficiency and diagnostic accuracy....Keywords: artificial intelligence; biomarker combinations; miRNA biomarkers; prostate cancer diagnosis; urinary extracellular vesicles. © 2025 Wiley‐VCH GmbH.
Reply to: Comment on "Multi-cancer early detection via a DNA methylation multiplex ddPCR-based blood test" [0.03%]
关于“基于DNA甲基化多重ddPCR的血液检测实现多癌症早期检测”的评论的回复
Vera Constâncio,Tiago Brito-Rocha,Rui Henrique et al.
Vera Constâncio et al.
Plasma fatty acids depletion: A metabolic signature related to colon cancer [0.03%]
与结直肠癌相关的代谢标志：等离子体脂肪酸耗尽
Alice Chaplin,Ramón M Rodríguez,Maria Barceló-Nicolau et al.
Alice Chaplin et al.
Patients with colon cancer (CC) have decreased plasma fatty acid (FA) content, yet few studies have undertaken a systemic approach to understand this phenomenon. Patients with CC (n = 172) and healthy controls (n = 17) were recruited for this study at the University Hospital Son Espases (Spain)....This reduction (≥50%) was consistent across all species, independently of sex, age, body composition or cancer stage. An elevated unsaturated-to-saturated FA ratio was observed in CMS2 tumours (p = 0.01).
Anticancer Potential of Myricetin against Huh7- and Hep3B-Derived Liver Cancer Stem Cells through the Regulation of Apoptosis, Autophagy, and Stemness [0.03%]
芦丁通过调控凋亡、自噬和干性抑制肝癌干细胞的抗肿瘤潜力
Mikyoung Kwon,Hye Jin Jung
Mikyoung Kwon
Liver cancer stem cells (LCSCs) play a significant role in the development, metastasis, treatment resistance, and recurrence of hepatocellular carcinoma (HCC). Targeting LCSCs offers a novel strategy to overcome treatment resistance in HCC....Keywords: Apoptosis; Autophagy; Chloroquine; Liver cancer stem cell; Myricetin.
Extracellular Vesicles From Prostate Cancer-Corrupted Osteoclasts Drive a Chain Reaction of Inflammatory Osteolysis and Tumour Progression at the Bone Metastatic Site [0.03%]
前列腺癌恶化破骨细胞源的细胞外囊泡驱动骨转移部位炎性溶骨和肿瘤进展的链式反应
Takaaki Tamura,Tomofumi Yamamoto,Akiko Kogure et al.
Takaaki Tamura et al.
Advanced-stage prostate cancer (PCa) frequently causes bone metastases, resulting in a poor prognosis and a 5-year survival rate of 30%. PCa bone metastasis is a highly complex and fluctuating process, comprising of osteolytic (bone-degrading) and osteogenic (bone-forming) lesions.
Ultrasonic Cavitation-Manipulated Macrophages Hitchhiking Augments Delivery of Nanocarriers for Active and Efficient Cancer Therapy [0.03%]
声空化介导的纳米药物载体携带巨噬细胞 hitchhiking 技术增强肿瘤内载药巨噬细胞递送用于高效激活抗肿瘤免疫治疗
Jiaxin Shen,Guowei Wang,Zixuan Huang et al.
Jiaxin Shen et al.
Cell-derived vehicles have shown promise in drug delivery for cancer therapy, but they are hindered by lack of effective methods to release drug from cellular vehicles....This study presents a promising strategy for efficient cancer therapy by utilizing ultrasound-regulated nanodrug-hitchhiking macrophages.
International Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate [0.03%]
国际泌尿病理学会关于癌前病变的共识。工作组一：前列腺
Kenneth A Iczkowski,Angelo M De Marzo,Neeraj Agarwal et al.
Kenneth A Iczkowski et al.
HGPIN need not be reported when concomitant cancer or atypical small acinar proliferation suspicious for cancer exists adjacent to it, for biopsy or prostatectomy specimens....Finally, while the clinical significance of unifocal HGPIN in biopsies remains uncertain, there is stronger evidence for multifocal isolated HGPIN as a predictor of subsequent cancer detection. By consensus, multifocal HGPIN should continue being reported....AIP found alone or with grade group 1 cancer warrants an explanatory comment. However, agreement was not attained to report AIP in the presence of invasive cancer, in either needle biopsy or prostatectomy.
Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer [0.03%]
用于三阴性乳腺癌复发诊断的细胞外囊泡蛋白质组分析改善了复发的诊断
Ju-Yong Hyon,Min Woo Kim,Kyung-A Hyun et al.
Ju-Yong Hyon et al.
We explored the diagnostic utility of tumor-derived extracellular vesicles (tdEVs) in breast cancer (BC) by performing comprehensive proteomic profiling on plasma samples from 130 BC patients and 40 healthy controls (HC)....ECM1, MBL2, BTD, and RAB5C. not only exhibited strong discriminatory performance, particularly for triple-negative breast cancer (TNBC), but also demonstrated potential relevance to disease recurrence, providing prognostic insights beyond initial diagnosis....Collectively, our results highlight the potential of EV proteomics as a minimally invasive, blood-based platform for both accurate detection and recurrence risk stratification in breast cancer and its aggressive subtypes, offering promising implications for future clinical applications.
Tumor-Targeted Radioiodinated Glyconanoparticles for Doxorubicin Delivery and Auger-Chemotherapy in Triple-Negative Breast Cancer [0.03%]
用于递送多柔比星和阿尔瓦-化疗的肿瘤靶向性放射性碘甘油纳米颗粒治疗三阴乳腺癌
Shishu Kant Suman,Biji Balakrishnan,Madhava B Mallia et al.
Shishu Kant Suman et al.
This study focuses on developing a tumor-responsive core-shell glyconanoparticle formulation targeting galectin-3 (Gal-3) in triple-negative breast cancer (TNBC) for Auger-chemotherapy....Keywords: auger radionuclide therapy; core‐shell glyconanoparticles; doxorubicin; iodine‐125; triple‐negative breast cancer (TNBC). © 2025 The Author(s). Small published by Wiley‐VCH GmbH.
Recent progress of dual-responsive fluorescent probes for polarity and analytes [0.03%]
近期用于极性和分析物的双刺激型荧光探针研究进展
Junru He,Xuwei Han,Yongkang Yue
Junru He
Their synergistic effect is closely linked to the emergence and advancement of atherosclerosis, diabetes, cancer and neurodegenerative diseases.
Review
The Analyst. 2025 Jun 23. DOI:10.1039/d5an00243e 2025
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