Comparative Genomics Reveals Conserved Ophiobolin Biosynthetic Gene Cluster and Necrotrophic Adaptation in Bipolaris oryzae [0.03%]
比较基因组学揭示了稻瘟病菌中橄榄霉素生物合成基因簇以及假隔垣营养适应性特征
Yoeguang Hue,Yebin Nam,Byungheon Choi et al.
Yoeguang Hue et al.
We identified 48 secondary metabolite biosynthetic gene clusters in B. oryzae F1253 and, critically, localized the ophiobolin biosynthetic gene cluster to pseudochromosome 2.
Exploring the biosynthetic potential of Korean Actinobacteria for antibacterial metabolite discovery [0.03%]
开发韩国放线菌的生物合成潜能以发现抗菌代谢物
Sehong Park,Hyun-Woo Je,Yujin Cha et al.
Sehong Park et al.
Additionally, genetic network analysis of biosynthetic gene clusters (BGCs) from 15 sequenced NIBR actinobacterial strains demonstrated extensive BGC diversity, with many clusters identified as cryptic.
Identification and Genomic Insights into the Biological Control and Growth-Promoting Mechanism of Bacillus velezensis L11-7, a Potential Biocontrol Agent of Passion Fruit Stem Basal Rot [0.03%]
枯萎病生物防治和促生菌芽孢杆菌L11-7的鉴定及其基因组学研究洞察
Ming Jin,Yuanfeng Tang,Rui Yang et al.
Ming Jin et al.
Its genome features a single circular 3.97 Mb chromosome harboring 13 s metabolite biosynthetic gene clusters (e.g., fengycin, surfactin, macrolactin H, bacillaene, difficidin) and genes encoding essential cell wall hydrolases.
Flagellimonas algicida sp. Nov.: A Novel Broad-Spectrum Algicidal Bacterium Targeting Harmful Algal Bloom Species and Genomic Insights into Its Secondary Metabolites [0.03%]
新型藻杀细菌鞭毛杆菌海藻噬藻型菌株的基因组及其次级代谢产物分析
Ning Wang,Yiling Liang,Hui Zhou et al.
Ning Wang et al.
Genome mining identified 11 biosynthetic gene clusters (BGCs), including those encoding for terpenes, ribosomal peptide synthetases, and non-ribosomal peptide synthetases.
New Marine Actinobacteria Strain, Micromonospora sp. SH-82: Characterization, Specialized Metabolites and Biological Activities [0.03%]
一株新的海分枝杆菌菌株Micromonospora sp. SH-82：特征，次级代谢产物和生物学功能
Alexandre Le Loarer,Laurence Marcourt,Rémy Marcellin-Gros et al.
Alexandre Le Loarer et al.
Genomic analysis identified this strain as a new species, revealing the presence of 23 biosynthetic gene clusters (BGCs), some of which are associated with the synthesis of specialized metabolites such as polyketides deriving from polyketide synthases (PKSs).
AdpA, a Global Regulator of Hundreds of Genes, Including Those for Secondary Metabolism, in Streptomyces venezuelae [0.03%]
AdpA是放线单孢菌委内瑞拉亚种中调控次级代谢等多个基因表达的全局调节因子
Marcin Wolański,Małgorzata Płachetka,Volha Naumouskaya et al.
Marcin Wolański et al.
However, most biosynthetic gene clusters (BGCs) remain silent under laboratory conditions. Global transcriptional regulators, such as AdpA, can activate these BGCs, but their roles in secondary metabolism are not fully understood.
Genomic and Phenotypic Characterization of a Drug-Susceptible Acinetobacter baumannii Reveals Increased Virulence-Linked Traits and Stress Tolerance [0.03%]
一株对药物敏感的耐药基因组和表型特征的肺炎克雷伯菌揭示了其与毒力相关性状和应激耐受性的增加
Wuen Ee Foong,Wenjun He,Xinxin Xiang et al.
Wuen Ee Foong et al.
Gene expression analysis revealed significant upregulation of heme utilization and siderophore biosynthetic gene clusters under serum exposure, indicating activation of iron uptake pathways under host-like conditions.
Diversity and Biotechnological Potential of Actinobacteria from the Krem Dam Cave, Meghalaya, India [0.03%]
印度梅加拉亚邦克雷姆大坝洞穴放线菌的多样性及其生物技术潜力
Debulman Syiemiong,Jintu Rabha,Ramasamy Vijayakumar et al.
Debulman Syiemiong et al.
Antimicrobial activity was assessed against Gram-positive, Gram-negative bacteria, and Candida species using cross-streak and agar-well diffusion methods, while biosynthetic gene clusters (PKS-I, PKS-II, NRPS) were screened via PCR.
Harnessing Epigenetic Modifiers Reveals MAPK-Mediated Regulation Mechanisms in Hadal Fungi of Alternaria alternata Under High Hydrostatic Pressure [0.03%]
表观遗传修饰揭示了高静水压下链格孢菌亚种交替变型菌丝体的MAPK介导调节机制
Qingqing Peng,Qifei Wei,Xi Yu
Qingqing Peng
High hydrostatic pressure (HHP) significantly modulates microbial metabolism, while chemical epigenetic modifiers are known to reactivate silent biosynthetic gene clusters and induce novel natural products.
Haplotype-Phased Chromosome-Level Genome Assembly of Floccularia luteovirens Provides Insights into Its Taxonomy, Adaptive Evolution, and Biosynthetic Potential [0.03%]
金丝桃属瑞典肝菌“染色体水平基因组的相容单倍型基因组组装为探讨其分类地位、适应性进化及生物合成潜力提供见解
Jianzhao Qi,Xiu-Zhang Li,Ming Zhang et al.
Jianzhao Qi et al.
AntiSMASH identified 15 biosynthetic gene clusters (BGCs), which encode diverse terpenoids (7), NRPS-like enzymes (4), PKSs (2), and a hybrid synthase with unique KS-AT-PT-A domains, which have the potential to generate novel metabolites.
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