Beyond the Bet: Exploring Gambling Disorder and Its Comorbidities: Case Series [0.03%]
超越赌注：探索赌博障碍及其共病：病例系列
R Selvameenatchi,Sylviah Immanuel,Sivabackiya Chithiravelu et al.
R Selvameenatchi et al.
NLRP3 inflammasome-driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors [0.03%]
独立于IL-1β和IL-18的NLRP3炎性体驱动的噬血细胞淋巴组织细胞增生症可被BET抑制剂靶向治疗
Farzaneh Shojaee,Esmaeel Azadian,Min Xian Wong et al.
Farzaneh Shojaee et al.
Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal cytokine storm syndrome. Its high mortality rate reflects limited therapeutic options and a poor understanding of disease-causing signaling. We show that the NLRP3 inflammasome...
YAP Upregulation Contributes to Acquired Resistance to BET Inhibitors in Uveal Melanoma [0.03%]
YAP上调对眼黑色素瘤获得性抵抗BET抑制剂的影响
Yan-Ling Zhou,Xiao-Lian Liu,Si-Si Huang et al.
Yan-Ling Zhou et al.
BET inhibitors have the potential to treat malignant tumors via the epigenetic modification mechanism. Although BET inhibitors show promise as anticancer agents for uveal melanoma (UM), the emergence of acquired resistance significantly lim...
A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC [0.03%]
一个Circular RNA通过拮抗IGF2BP2介导的c-MYC翻译来克服BET抑制剂获得性耐药在三阴性乳腺癌中的作用
Jiawei Guo,Ke Li,Yue Ming et al.
Jiawei Guo et al.
Bromodomain-and-extraterminal-domain (BET) proteins are promising therapeutic targets for refractory solid tumors, including triple-negative breast cancer (TNBC). However, acquired resistance to BET inhibitors (BETi) remains a significant c...
BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature-positive castration-resistant prostate cancer [0.03%]
BET抑制剂可减少胃肠基因特征阳性去势抵抗性前列腺癌的临床前模型中的肿瘤生长
Shipra Shukla,Dan Li,Woo Hyun Cho et al.
Shipra Shukla et al.
A subgroup (~20-30%) of castration-resistant prostate cancer (CRPC) aberrantly expresses a gastrointestinal (GI) transcriptome governed by two GI-lineage-restricted transcription factors, HNF1A and HNF4G. In this study, we found that expres...
Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets [0.03%]
转录因子T-bet调节淋巴结和肺效应记忆B细胞亚群的维持和分化潜能
Christopher A Risley,Michael D Schultz,S Rameeza Allie et al.
Christopher A Risley et al.
While human and mouse memory B cells (MBCs) can express the transcription factor T-bet, its role in regulating MBC function remains unclear. We characterized multiple transcriptionally distinct clusters of mature, somatically mutated nucleo...
Maximizing bacterial survival: integrating sense-and-respond and bet-hedging mechanisms [0.03%]
利用感应与响应及投机下注机制最大化细菌存活率
Lillian C Lowrey,Nicole C Gadda,Rita Tamayo
Lillian C Lowrey
Two-component systems allow bacteria to respond to specific environmental signals with defined adaptive phenotypic changes, a process that requires time and may be inadequate for contending with rapidly changing environments. In contrast, p...
Bet More - But Only with Me: Role of Celebrity Endorsers in Sports Betting Advertising [0.03%]
名人效应在体育博彩广告中的作用
Wenjia Han,Vaidyanathan Viswanathan Saunak
Wenjia Han
Since the federal ban on sports betting was lifted in 2018, the industry has grown rapidly in the United States, raising concerns about the risk of problem gambling. Building on existing research that suggests the limited effectiveness of t...
The roles of histone acetylation key enzymes HAT, HDAC and BET proteins in neuropathic pain:selection of drug targets [0.03%]
组蛋白乙酰化关键酶HAT、HDAC和BET蛋白在神经病理性疼痛中的作用及药物靶点选择
Xingyu Wang,Huiyu Luo
Xingyu Wang
Histone acetylation is currently one of the epigenetic mechanisms that have been extensively and profoundly studied, and is associated with the occurrence and development of various diseases such as cancer and neurodegenerative disorders.Hi...
Modeling Human Airway Epithelial Barrier Penetration Using Birch Bet v 1 and Alder Aln g 1 Pollen Allergens During Sensitization Process [0.03%]
利用欧洲赤松Bet v 1和欧洲鹅耳枥Aln g 1花粉过敏原建立上呼吸道上皮屏障渗透模型及过敏过程中的动态变化
Daria N Melnikova,Andrey E Potapov,Tatiana V Ovchinnikova et al.
Daria N Melnikova et al.
Pollen allergy is rated as a major public health problem, causing significant morbidity and adversely affecting the quality of people's lives. The airway epithelium serves as the first line of defense in the respiratory system, playing a cr...
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