Breaking tolerance in the glomerulus: complement as a driver and therapeutic target in IgA nephropathy
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IgA nephropathy (IgAN) is an established autoimmune glomerular disease driven by mucosal tolerance failure, aberrant IgA1 glycosylation, and anti-glycan autoantibody formation. Mesangial deposition of galactose-deficient IgA1 (Gd-IgA1) complexes remains the ce... ...
