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A Biomimetic Nanoplatform Alleviates Depression via GRP75-Targeted Mitochondria-Associated Endoplasmic Reticulum Membranes Disassembly and Nanozyme-Driven ROS Scavenging

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Dysfunction of microglial mitochondria-associated endoplasmic reticulum membranes (MAMs) and excessive oxidative stress are emerging pathological features of depression. Here, we developed P/F-Rg1@M, a macrophage-biomimetic nanomedicine designed to restore mic... ...