Caffeic acid phenethyl ester derivatives inhibit glyoxalase I activity and induce cell death in cultured cancer cell lines
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Glyoxalase I (GLO I) is the rate-limiting enzyme responsible for the detoxification of methylglyoxal, a toxic byproduct of anaerobic glycolysis. GLO I is highly expressed in various tumors and has therefore been recognized as a promising target for cancer ther... ...
