IRF8 transcriptionally drives NAIP to promote NLRP3/NLRC4 inflammasome-mediated renal tubular pyroptosis in diabetic kidney disease
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Objective: Renal tubular pyroptosis is a key driver of inflammation and fibrosis in diabetic kidney disease (DKD), yet the contribution of the NAIP-NLRC4 inflammasome arm and its upstream transcriptional control have remained und... ...
