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An Emodin-Depot Microsphere-in-Hydrogel Reprograms the Immuno-myogenic Niche to Enable Volumetric Muscle Loss Repair Revealed by Single-Cell Profiling

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Volumetric muscle loss (VML) causes irreversible loss of contractile tissue and creates a hostile regenerative niche marked by sustained inflammation, oxidative stress, fibrosis, and poor functional recovery. Here, we develop an injectable and photocurable mic... ...