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Brain-seeded 42-residue amyloid-β fibrils that resemble fibrils directly extracted from Alzheimer's disease brain tissue

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Fibrils formed by the 42-residue amyloid-β peptide (Aβ42) are known to be polymorphic, with molecular conformations and supramolecular structures that depend on conditions of nucleation, growth, seeding, or other factors. Structural studies of Aβ42 fibrils ... ...