The discovery of potent and selective N6-modified adenosine derivatives as effective chemotherapeutic agents to overcome p53-dependent drug resistance in cancer and HPIV-3/AdV5 respiratory tract infections
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A library of N6-modified adenosine derivatives (compounds 7-36) was synthesized via a one-step reaction of 6-chloro- or 2-amino-6-chloro-(β-D-ribofuranosyl)-9H-purine with primary or secondary amines. The structures of selected compounds (14, 31, 34) were con... ...
