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Preclinical evaluation of itraconazole in docetaxel-resistant prostate cancer xenograft models

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Docetaxel (DTX) resistance remains a major barrier in metastatic prostate cancer, often driven by ABCB1 efflux and activation of survival pathways. We investigated the therapeutic impact of itraconazole (ITZ), a multifunctional antifungal agent with activity a... ...