Creatine preserves mitochondrial integrity and ameliorates early epileptiform activity and cognitive impairment via regulation of Na⁺,K⁺-ATPase in adolescent rats with severe traumatic brain injury
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In this study, we demonstrate for the first time that post-injury creatine supplementation (300 mg/kg, p.o.) administered for two weeks attenuates blood-brain barrier disruption, cortical lesion volume (by ∼60%), spatial memory deficits (reducing escape laten... ...