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Structure-based identification of novel indole-fused polycyclic derivatives as potent acetylcholinesterase inhibitors

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The pathogenesis of Alzheimer's disease (AD) is closely associated with cholinergic neuronal impairment, which is induced by excessive degradation of acetylcholine (ACh) mediated by acetylcholinesterase (AChE). In this study, a series of novel indole-fused po... ...