Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation
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Adenine-thymine (AT)-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) that post-transcriptionally stabilizes mRNAs encoding proinflammatory mediators, including Interleukin-6 (IL-6), thereby amplifying inflammation. Howeve... ...
