Differential Na+ chelation underlies opposite effects of aconitine and bulleyaconitine on sodium channel permeation
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Voltage-gated sodium (Nav) channel site-2 diterpenoid alkaloids, including potent toxin aconitine (ACO), are generally considered gating modifiers that stabilize activated/open conformations and impair fast inactivation. In contrast, the structurally related c... ...
