Loss of SETD2-mediated H3K36me3 Drives CD8+ T Cell Exhaustion in Lung Cancer through CXCL-dependent PMN-MDSC Recruitment and Arginine Deprivation
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Immune evasion in lung cancer is tightly regulated by epigenetic mechanisms. This study identifies key epigenetic drivers of immune escape in lung cancer and elucidates how they remodel the tumor microenvironment to induce CD8+ T cell exhaustion. We performed ... ...