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MARCH8 inhibits PRRSV-2 replication by targeting viral GP5 for proteasomal degradation at a conserved lysine 163

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Porcine reproductive and respiratory syndrome virus (PRRSV) continues to pose a significant threat to global swine production. In China, PRRSV type 2 (PRRSV-2) is the predominant strain, and the inadequate cross-protection provided by existing vaccines highlig... ...