Biocatalytic reduction of nitro-sulfonamides: enzyme engineering, process integration, and sustainable pathways to p-aminobenzenesulfonamide
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Sulfonamides remain important to medicinal and fine-chemical production but conventional aniline precursor routes like Pd-catalysed hydrogenation and Béchamp reductions carry sustainability, safety, and chemoselectivity challenges, especially for N-S bond int... ...
