Systematic metabolic engineering of Escherichia coli for high-level production of trans-4-hydroxy-L-proline
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As a high-value-added amino acid derivative, trans-4-hydroxy-L-proline (T-4-Hyp) faces key bottlenecks in its microbial production from glucose, including insufficient precursor supply and an imbalance between cell growth and product biosynthesis. In this stud... ...
