A rare variant in DPYD c.812delT causes severe adverse events of S-1 in a patient with tongue cancer
{{output}}
Dihydropyrimidine dehydrogenase (DPD), which is encoded by the DPYD gene, plays an important role in the metabolism of fluoropyrimidine (FP) drugs, including tegafur, in S-1. A decrease in DPD activity can cause severe FP-related toxicity. The Clinical Pharmac... ...
