Methodological Concerns in a Recently Published Systematic Review and Meta-Analysis of Xanomeline-Trospium in Schizophrenia : Re: Azargoonjahromi A, Nasiri H. Efficacy and Safety of KarXT (Xanomeline-Trospium; Cobenfy™) in Schizophrenia: A Systematic and Meta-Analysis Review of Randomized Controlled Trials. Psychiatric Quarterly. 2025. https://doi.org/1
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This letter addresses significant methodological limitations in a recently published systematic review and meta-analysis evaluating the efficacy and safety of xanomeline-trospium (KarXT) in schizophrenia. A critical unit-of-analysis error is identified in the ... ...
