Falls induced by optogenetic inhibition of basal forebrain cholinergic neurons after dorsomedial striatal dopamine depletion in a dual disruption model of falling vulnerability in Parkinson's disease
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Falls are a common and debilitating feature of Parkinson's Disease (PD) patients. Prefrontal acetylcholine (ACh) deficits, as well as nigrostriatal dopamine deficits, are implicated in vulnerability to falls. PD patients with loss of cortical ACh and associat... ...
