Haploidentical hematopoietic stem cell transplantation drives time-dependent premature T cell senescence: Recipient microenvironment modulates donor T cell epigenetic aging, telomere homeostasis and SASP remodeling
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Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) cures hematological malignancies but severely impairs long-term immune reconstitution by inducing T cell senescence. Previous studies have linked anti-tum... ...
