"SMAC"-down for the apoptosis-restoring drug, Xevinapant: What does its story reveal?
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Xevinapant, an antagonist of inhibitor of apoptosis proteins (IAPs) from the SMAC-mimetic drug class, was developed to restore apoptosis in cancer cells. Preclinical studies demonstrated on-target IAP degradation, caspase activation, and pro-inflammatory apopt... ...
