Reply to Kelly M. de Ligt, Sarah P. Psutka, and Laura S. Mertens's Letter to the Editor Re: Martino Pedrani, Alberto De Giorgi, Andrea Gallina, et al. When Patients Refuse Radical Cystectomy: Integrating Trimodality Therapy in the Perioperative ICI/ADC Era. Eur Urol Oncol. In press. http://dx.doi.org/10.1016/j.euo.2026.04.008