Pharmacological targeting of the extracellular cGAMP-ENPP1 axis in cancer immunotherapy: mechanisms, biomarkers, and translational strategies
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The extracellular cyclic GMP-AMP (cGAMP)-ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) axis is an emerging pharmacological target that links tumor-intrinsic DNA stress to antitumor immunity. Tumor cells can generate cGAMP in response to chromosoma... ...
