Three-dimensional single-particle reconstruction by atomic force microscopy imaging and template matching allows rapid structural-based validation of recombinant SARS-CoV-2 Spike protein from a single topology image
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Atomic force microscopy (AFM) is a versatile multi-modal imaging method frequently used for structural characterisation of biological surfaces at the nanoscale. However, AFM-based three-dimensional single-particle reconstruction has hitherto not been possible ... ...
