Coordinated RNA- and protein-templated synthesis of double-stranded DNA by a dual reverse transcriptase immune system
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Defense-associated reverse transcriptase (DRT) systems mediate antiviral immunity through distinct modes of cDNA synthesis: class 1 DRTs catalyze untemplated synthesis, whereas class 2 DRTs polymerize non-coding RNA-templated products. However, how these disti... ...
