Stereoisomer-specific allosteric activation of xanthine oxidoreductase by shikonin and alkannin: mechanistic insights and hyperuricemia risk assessment
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Xanthine oxidoreductase (XOR), the rate-limiting enzyme in uric acid metabolism, reversibly interconverts between dehydrogenase (XDH) and oxidase (XO) forms. Our previous study revealed allosteric activation of XOR by 1,4-naphthoquinones, highlighting their po... ...
