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Development of karapinchamine A-related carbazoles with antiproliferative activity against glioblastoma-derived cancer stem cells and blood-brain barrier permeability

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Karapinchamine A (1)-a geranylated carbazole isolated from the leaves of Bergera koenigii (syn. of Murraya koenigii) (curry leaf)-was synthesized together with twelve N-substituted carbazole derivatives. Their antiproliferative activities were evaluated agains... ...