Balancing sample size and accuracy of dose selection in phase 1 oncology trials - designs tiered by cohort size and maximum number of patients treated per dose
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The objective of phase 1 oncology dose‑escalation trials is to identify the dose with a toxicity rate that matches or is the closest to the target dose‑limiting toxicity (DLT). There are mainly two categories of design methods for phase 1 trials: the rule-ba... ...
