Discovery of 1 H-Indole-3-Propionamide Derivatives as Potent, Selective and Orally Available NaV1.7 Inhibitors for Pain Treatment
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Dysfunction of the voltage-gated sodium channel NaV1.7 underlies multiple pain-sensitivity disorders, making NaV1.7 inhibition an attractive therapeutic strategy. However, currently available NaV1.7 inhibitors, frequently suffer from limited structural diversi... ...
