Proteomic alterations in patient bone-derived stromal cells and their secretomes in osteogenesis imperfecta
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Type I collagen is the most abundant form of collagen and forms the organic component of bone. Pathogenic variants in genes encoding its constituent polypeptide chains, COL1A1 and COL1A2, can result in autosomal dominant osteogenesis imperfecta and other conne... ...
