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Photodynamic therapy based on indomethacin-conjugated photosensitizers: targeting cyclooxygenase-2 in cancer treatment

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FactsPhotodynamic therapy (PDT) kills cancer cells via the generation of reactive oxygen species but can also trigger harmful protumorigenic effects.Cyclooxygenase-2 (COX-2) overexpression and prostaglandin E2 secretion limit PDT efficacy in many tumors.Combin... ...