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MMF inhibits poxvirus infection by disrupting IMPDH2 interaction with USP5 and inducing its Rod-and-Ring assemblies

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Monkeypox virus (MPXV), a pathogenic orthopoxvirus, has caused major outbreaks and emerged as a global public health threat. Although antivirals approved for smallpox are used therapeutically against monkeypox, their clinical utility is limited by drug availab... ...