Scaffold hopping-directed design and discovery of N1-substituted aminopyrimidine-indole derivatives as FAK inhibitors with anti-pancreatic cancer activity
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Pancreatic cancer, characterized by its highly aggressive malignancy and suboptimal clinical outcomes, remains a formidable global health challenge. Focal adhesion kinase (FAK) functions as a pivotal modulator of diverse cellular pathways, representing a well-... ...
