Targeting the NAD+ salvage pathway: Identification of bifunctional NAMPT inhibitors and SIRT1 activators through pharmacophore-based virtual screening
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Nicotinamide phosphoribosyltransferase (NAMPT) and Sirtuin 1 (SIRT1) are key regulators of cellular metabolism and NAD+ homeostasis, representing attractive targets in cancer therapy. In this study, we identified novel bifunctional small molecules acting as si... ...
