Efficient generation of human cDC1-like cells to detect and enhance tumor-reactive T cells via CD4+ T cell help
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Classical type 1 dendritic cells (cDC1s) are crucial to anti-tumor immunity by cross-presenting tumor antigens and priming cytotoxic CD8+ T lymphocytes (CTLs). Licensing via CD4+ T cell help endows cDC1s with enhanced cross-presentation and CTL-priming capacit... ...
