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Aseptic Thermochemical Shock after Hyperthermic Intrathoracic Chemotherapy: Pathophysiological Mechanisms and a Translational Framework for Perioperative Management

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Hyperthermic intrathoracic chemotherapy has emerged as a promising locoregional therapy for pleural malignancies. However, the combination of surgical trauma, intrathoracic hyperthermia, and cytotoxic exposure to cisplatin can trigger a complex systemic inflam... ...