Ordinary Differential Equation-Based Individualized Pharmacokinetic Simulation for Dose Optimization in an Infant with Global Developmental Delay and Drug-Resistant Epilepsy
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In children with epilepsy associated with global developmental delay (GDD), around 10-20% experience refractory epilepsy, often requiring multiple antiseizure drugs (ASDs). These ASDs have narrow therapeutic indices. Therapeutic drug monitoring is crucial for ... ...
