Osteocalcin-dependent and -independent metabolic dysregulation in a mouse model of Osteogenesis imperfecta
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Osteogenesis imperfecta (OI) is a rare bone fragility disorder. Previously, in a severe OI mouse model (Col1a1Jrt/+), a sex- and age-dependent metabolic phenotype was observed, correlating with elevated levels of the bone-derived hormone osteocalcin (OCN). Thi... ...
