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Plasmid design, cloning, and expression of Vitreoscilla hemoglobin in Streptomyces pilosus: a novel strategy to enhance desferrioxamine B production and yield

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Streptomyces pilosus is the primary producer of desferrioxamine B (DFOB), to treat acute and chronic iron overload. Its growth and productivity depend on dissolved oxygen concentration. Vitreoscilla hemoglobin (VHb enhances oxygen transfer and metabolic effici... ...