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Collagen sponge combined with recombinant human basic fibroblast growth factor for refractory venous leg ulcers: A prospective controlled study evaluating healing, skin graft avoidance, and costs

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Background: Refractory venous leg ulcers (VLUs) represent a significant clinical challenge, often requiring surgical intervention with skin grafting. This study evaluated whether a collagen sponge combined with recombinant human ... ...