Clinical outcomes after transition from weight-based to fixed-dose glucarpidase for high-dose methotrexate toxicity at a large academic medical center
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IntroductionDelayed methotrexate clearance can result in life-threatening toxicities including renal failure. Treatment includes vigorous hydration, urine alkalinization, leucovorin rescue, and glucarpidase. While traditional glucarpidase dosing is weight-base... ...
