Targeting Warburg effect in Chinese hamster ovary cell culture with pyruvate dehydrogenase kinase inhibitors
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Production of monoclonal antibodies (mAbs) in Chinese hamster ovary (CHO) cells is affected by the "Warburg effect" which is characterized by high lactate accumulation. Therefore, the present study explores the use of pyruvate dehydrogenase kinase (PDK) inhi... ...
